Patients with early age-related macular degeneration exhibit signs of macro- and micro-vascular disease and abnormal blood glutathione levels

Qin, Lu; Mroczkowska, Stephanie A.; Ekart, Aniko; Patel, Sunni R.; Gibson, Jonathan M. and Gherghel, Doina (2013). Patients with early age-related macular degeneration exhibit signs of macro- and micro-vascular disease and abnormal blood glutathione levels. Graefe's archive for clinical and experimental ophthalmology, Online first ,

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Official URL: http://link.springer.com/article/10.1007%2Fs00417-...

Abstract

Background - This pilot study aimed to investigate systemic and retinal vascular function and their relationship to circulatory markers of cardiovascular risk in early age-related macular degeneration (AMD) patients without any already diagnosed systemic vascular pathologies. Methods - Fourteen patients diagnosed with early AMD and 14 age- and gender-matched healthy controls underwent blood pressure, carotid intima-media thickness (C-IMT) and peripheral arterial stiffness measurements. Retinal vascular reactivity was assessed by means of dynamic retinal vessel analysis (DVA) using a modified protocol. Blood analyses were conducted for glutathione levels and plasma levels of total cholesterol (CHOL), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and triglycerides (TG). Results - The AMD patients showed significantly greater C-IMT (p?=?0.029) and augmentation index (AIx) (p?=?0.042) than the age-matched controls. In addition, they demonstrated a shallower retinal arterial dilation slope (Slope AD) (p?=?0.005) and a longer retinal venous reaction time (RT) to flickering light (p?=?0.026). Blood analyses also revealed that AMD patients exhibited higher oxidized glutathione (GSSG) (p?=?0.024), lower redox index (p?=?0.043) and higher LDL-C (p?=?0.033) levels than the controls. Venous RT parameter correlated positively with blood GSSG levels (r?=?0.58, p?=?0.038) in AMD subjects, but not in the controls (p?>?0.05). Conclusions - Patients diagnosed with early AMD exhibit signs of systemic and retinal vascular alterations that correlated with known risk markers for future cardiovascular morbidity.

Item Type:Article
Uncontrolled Keywords:age-related macular degeneration, microvascular function, oxidative stress, retinal vascular function
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ID Code:19695
Deposited By:Prof Alfred Admin
Deposited On:24 Jul 2013 09:15
Last Modified:20 Feb 2014 08:24

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