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Armstrong, Richard A.; Myers, D. and Smith, Christopher U.M. (1995). What determines the size frequency distribution of β-amyloid (Aβ) deposits in Alzheimer's disease patients? Neuroscience letters, 187 (1), pp. 13-16.

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The factors determining the size of individual β-amyloid (A,8) deposits and their size frequency distribution in tissue from Alzheimer's disease (AD) patients have not been established. In 23/25 cortical tissues from 10 AD patients, the frequency of Aβ deposits declined exponentially with increasing size. In a random sample of 400 Aβ deposits, 88% were closely associated with one or more neuronal cell bodies. The frequency distribution of (Aβ) deposits which were associated with 0,1,2,...,n neuronal cell bodies deviated significantly from a Poisson distribution, suggesting a degree of clustering of the neuronal cell bodies. In addition, the frequency of Aβ deposits declined exponentially as the number of associated neuronal cell bodies increased. Aβ deposit area was positively correlated with the frequency of associated neuronal cell bodies, the degree of correlation being greater for pyramidal cells than smaller neurons. These data suggested: (1) the number of closely adjacent neuronal cell bodies which simultaneously secrete Aβ was an important factor determining the size of an Aβ deposit and (2) the exponential decline in larger Aβ deposits reflects the low probability that larger numbers of adjacent neurons will secrete Aβ simultaneously to form a deposit. © 1995.

Item Type:Article
Uncontrolled Keywords:Alzheimer's disease,negative exponential model,neuronal cell bodies,size class frequency distribution,β-Amyloid (Aβ),Neuroscience(all)
Divisions:Schools_of_Study > Life & Health Sciences > Optometry (LHS)
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ID Code:17591
Deposited By:Prof Alfred Admin
Deposited On:25 Oct 2012 09:48
Last Modified:20 Jul 2015 10:30

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