Aston Research Explorer
Brazzo, Daniela; Di Lorenzo, Giorgio; Bill, P.; Fasce, M.; Papalia, G.; Veggiotti, P. and Seri, Stefano (2011). Abnormal visual habituation in pediatric photosensitive epilepsy. Clinical neurophysiology, 122 (1), pp. 16-20.
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Objective - To investigate visual habituation – a measure of visual cortical excitability – in photosensitive patients in pediatric age and compare the findings with a matched sample with idiopathic generalized epilepsies without photosensitivity and with normally developing children. Methods - We presented a full-field black-and-white checkerboard pattern, at 3 reversal/s with 100% contrast binocularly for 600 consecutive trials and measured the N75–P100 and P100–N145 pattern-reversal visual evoked potential inter-peak amplitudes and N75, P100, N145 latencies for the six blocks of 100 responses. As a measure of habituation we used the slope of the linear regression line of the N75–P100 and P100–N145 peak-to-peak amplitudes. The slope of the linear regression line of the N75–P100 and P100–N145 latencies was also analyzed. Results - Statistical analysis revealed significant differences between the three groups in the slope index of N75–P100 PR-VEP amplitude, with increased or constant amplitude in the PS group compare to the IGE and ND across the six blocks. Conclusions - Our results support the notion that photosensitivity is associated with altered control of excitatory and inhibitory cortical processes. The causal relationship between habituation deficit and photo-paroxysmal response needs to be further investigated with longitudinal studies. Significance This study supports the hypothesis that suppression of PR-VEP is a sensitive intermediate phenotype, which discriminates patients with photosensitivity from those with generalized epilepsies in pediatric age.
|Additional Information:||Copyright © 2010 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.|
|Uncontrolled Keywords:||photosensitivity, epilepsy, habituation, sensory gating, pattern-reversal VEP, Clinical Neurology, Neurology, Physiology (medical), Sensory Systems|
|Divisions:||Schools_of_Study > Life & Health Sciences|
Schools_of_Study > Life & Health Sciences > Psychology (LHS)
|Deposited By:||Prof Alfred Admin|
|Deposited On:||13 Sep 2012 08:11|
|Last Modified:||21 Nov 2014 08:18|
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